ATLANTA and PARSIPPANY, N.J., July 7, 2020 /PRNewswire/ -- UCB and Ferring Pharmaceuticals Inc. today announced they have entered into a co-promotion agreement to commercialize the prefilled syringe formulation of CIMZIA® (certolizumab pegol) in the United States, specifically for the treatment of Crohn's disease (CD). Ferring will take over marketing, sales promotion, and field medical affairs activities. UCB will continue to be responsible for all product-related activities, including revenue recognition. CIMZIA is an injectable biologic treatment option for adults with moderate to severe Crohn's disease with inadequate response to conventional therapy. UCB will continue to promote and to commercialize the lyophilized formulation of CIMZIA for all indications as well as the prefilled syringe formulation for CIMZIA's rheumatology and dermatology indications.

"UCB is committed to serving the needs of immunology patients, including those living with Crohn's disease. We are excited about this opportunity as it will expand the awareness to the benefits of CIMZIA for individuals living with moderate to severe Crohn's disease, while continuing to support patients through our services and programs," said Camille Lee, Head of U.S. Immunology at UCB. "We believe UCB and Ferring are a strategic fit for the co-promotion as both companies have a strong patient-focused commitment and Ferring has expertise in gastroenterology. UCB is preparing for future launches in immunology, demonstrating our commitment to patients with severe chronic diseases."

This co-promotion allows Ferring to expand its growing portfolio in the gastrointestinal space and support patients living with Crohn's disease, while enabling UCB to focus on and prepare for the future.

"Ferring is focusing on gut health as we expand our gastroenterology portfolio," said Brent Ragans, President of Ferring US. "Together with our existing portfolio, this agreement with UCB will allow Ferring to offer treatment options to the nearly 800,000 adult patients in the U.S. who suffer from Crohn's disease."

CIMZIA has been a treatment option for adults living with moderate to severe Crohn's disease over the last 12 years, since it was approved by the FDA in 2008 based on safety and efficacy data from clinical trials in more than 1,500 patients with Crohn's disease.

CIMZIA can be administered either through self-injection or by a healthcare professional.1 CIMZIA can lower the ability to fight infections. Some people who received CIMZIA have developed serious infections, including tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body.1 Some of these serious infections have caused hospitalization and death.1

About Crohn's disease

Crohn's disease is an inflammatory bowel disease causing chronic inflammation of the gastrointestinal (GI) tract.2 Crohn's disease can affect any part of the GI tract from mouth to anus, most commonly involving the ileum and proximal colon.3 It belongs to a group of conditions known as inflammatory bowel diseases, or IBD.4 The disease can occur at any age, but is most often diagnosed in adolescents and adults between the ages of 20 and 30.2 Approximately 780,000 Americans are currently affected by Crohn's disease.3

Patients with Crohn's disease may present acutely or have a history of symptoms prior to confirming diagnosis.4 A hallmark symptom in patients with Crohn's disease is abdominal pain.4 Other symptoms include diarrhea potentially persistent in nature,GI bleeding, urgent need to move bowels,abdominal cramps,sensation of incomplete bowel evacuationand constipation, which can lead to bowel obstruction.4

About CIMZIA® in the US

CIMZIA is the only Fc-free, PEGylated anti-TNF (Tumor Necrosis Factor). CIMZIA has a high affinity for human TNF-alpha, selectively neutralizing the pathophysiological effects of TNF-alpha.

CIMZIA is indicated for reducing signs and symptoms of Crohn's disease (CD) and maintaining clinical response in adult patients with moderately to severely active disease who have had an inadequate response to conventional therapy.

CIMZIA is also indicated for the treatment of adults with moderately to severely active rheumatoid arthritis (RA), adults with active psoriatic arthritis (PsA), adults with active ankylosing spondylitis (AS), and adults with active non-radiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation.

In addition, CIMZIA is indicated for the treatment of moderate to severe plaque psoriasis (PSO) in adults who are candidates for systemic therapy or phototherapy. See important safety information including risk of serious bacterial, viral and fungal infections and tuberculosis below.

IMPORTANT SAFETY INFORMATION about CIMZIA in the U.S.

CONTRAINDICATIONS

CIMZIA is contraindicated in patients with a history of hypersensitivity reaction to certolizumab pegol or to any of the excipients. Reactions have included angioedema, anaphylaxis, serum sickness, and urticaria.

SERIOUS INFECTIONS

Patients treated with CIMZIA are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids.

Discontinue CIMZIA if a patient develops a serious infection or sepsis.

Reported infections include:

Carefully consider the risks and benefits of treatment with CIMZIA prior to initiating therapy in the following patients: with chronic or recurrent infection; who have been exposed to TB; with a history of opportunistic infection; who resided in or traveled in regions where mycoses are endemic; with underlying conditions that may predispose them to infection. Monitor patients closely for the development of signs and symptoms of infection during and after treatment with CIMZIA, including the possible development of TB in patients who tested negative for latent TB infection prior to initiating therapy.

MALIGNANCY

Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, of which CIMZIA is a member. CIMZIA is not indicated for use in pediatric patients.

HEART FAILURE

HYPERSENSITIVITY

HEPATITIS B VIRUS REACTIVATION

NEUROLOGIC REACTIONS

HEMATOLOGIC REACTIONS

DRUG INTERACTIONS

AUTOIMMUNITY

IMMUNIZATIONS

ADVERSE REACTIONS

For full prescribing information, please visit https://ucb-usa.com/_up/ucb_usa_com_kopie/documents/Cimzia_PI.pdf

References:

CIMZIA® is a registered trademark of the UCB Group of Companies.

For further information, Ferring Pharmaceuticals:

Heather Guzzi Director, Brand Communications (862) 286-5254 (direct) (973) 769-3999 (mobile) heather.guzzi@ferring.com

For further information, UCB: U.S. Communications Allyson Funk Communications, U.S. T. 770.970.8338, allyson.funk@ucb.com

Investor Relations Antje Witte Investor Relations, UCB T +32.2.559.94.14, antje.witte@ucb.com

Isabelle Ghellynck Investor Relations, UCB T+32.2.559.9588, isabelle.ghellynck@ucb.com

About UCB UCB, Brussels, Belgium (www.ucb.com) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With more than 7 600 people in approximately 40 countries, the company generated revenue of 4.9 billion in 2019. UCB is listed on Euronext Brussels (symbol: UCB). Follow us on Twitter: @UCBUSA

About Ferring Pharmaceuticals Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group committed to helping people around the world build families and live better lives. In the United States, Ferring is a leader in reproductive medicine and maternal health, and in specialty areas within gastroenterology and orthopaedics. For more information, call 1-888-FERRING (1-888-337-7464); visit http://www.FerringUSA.com

Forward looking statements UCB This press release may contain forward-looking statements including, without limitation, statements containing the words "believes", "anticipates", "expects", "intends", "plans", "seeks", "estimates", "may", "will", "continue" and similar expressions. These forward-looking statements are based on current plans, estimates and beliefs of management. All statements, other than statements of historical facts, are statements that could be deemed forward-looking statements, including estimates of revenues, operating margins, capital expenditures, cash, other financial information, expected legal, arbitration, political, regulatory or clinical results or practices and other such estimates and results. By their nature, such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions which might cause the actual results, financial condition, performance or achievements of UCB, or industry results, to differ materially from those that may be expressed or implied by such forward-looking statements contained in this press release. Important factors that could result in such differences include: the global spread and impact of COVID-19, changes in general economic, business and competitive conditions, the inability to obtain necessary regulatory approvals or to obtain them on acceptable terms or within expected timing, costs associated with research and development, changes in the prospects for products in the pipeline or under development by UCB, effects of future judicial decisions or governmental investigations, safety, quality, data integrity or manufacturing issues; potential or actual data security and data privacy breaches, or disruptions of our information technology systems, product liability claims, challenges to patent protection for products or product candidates, competition from other products including biosimilars, changes in laws or regulations, exchange rate fluctuations, changes or uncertainties in tax laws or the administration of such laws, and hiring and retention of its employees. There is no guarantee that new product candidates will be discovered or identified in the pipeline, will progress to product approval or that new indications for existing products will be developed and approved. Movement from concept to commercial product is uncertain; preclinical results do not guarantee safety and efficacy of product candidates in humans. So far, the complexity of the human body cannot be reproduced in computer models, cell culture systems or animal models. The length of the timing to complete clinical trials and to get regulatory approval for product marketing has varied in the past and UCB expects similar unpredictability going forward. Products or potential products which are the subject of partnerships, joint ventures or licensing collaborations may be subject to differences disputes between the partners or may prove to be not as safe, effective or commercially successful as UCB may have believed at the start of such partnership. UCB's efforts to acquire other products or companies and to integrate the operations of such acquired companies may not be as successful as UCB may have believed at the moment of acquisition. Also, UCB or others could discover safety, side effects or manufacturing problems with its products and/or devices after they are marketed. The discovery of significant problems with a product similar to one of UCB's products that implicate an entire class of products may have a material adverse effect on sales of the entire class of affected products. Moreover, sales may be impacted by international and domestic trends toward managed care and health care cost containment, including pricing pressure, political and public scrutiny, customer and prescriber patterns or practices, and the reimbursement policies imposed by third-party payers as well as legislation affecting biopharmaceutical pricing and reimbursement activities and outcomes. Finally, a breakdown, cyberattack or information security breach could compromise the confidentiality, integrity and availability of UCB's data and systems.

Given these uncertainties, you should not place undue reliance on any of such forward-looking statements. There can be no guarantee that the investigational or approved products described in this press release will be submitted or approved for sale or for any additional indications or labelling in any market, or at any particular time, nor can there be any guarantee that such products will be or will continue to be commercially successful in the future.

UCB is providing this information, including forward-looking statements, only as of the date of this press release and it does not reflect any potential impact from the evolving COVID-19 pandemic, unless indicated otherwise. UCB is following the worldwide developments diligently to assess the financial significance of this pandemic to UCB. UCB expressly disclaims any duty to update any information contained in this press release, either to confirm the actual results or to report or reflect any change in its forward-looking statements with regard thereto or any change in events, conditions or circumstances on which any such statement is based, unless such statement is required pursuant to applicable laws and regulations.

Additionally, information contained in this document shall not constitute an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any offer, solicitation or sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of such jurisdiction.

USP-CZ-CD-2000038

View original content to download multimedia:http://www.prnewswire.com/news-releases/ucb-and-ferring-pharmaceuticals-announce-co-promotion-of-cimzia-certolizumab-pegol-for-the-treatment-of-adults-with-moderate-to-severe-crohns-disease-301089326.html

SOURCE UCB, Inc.

Go here to read the rest:
UCB and Ferring Pharmaceuticals Announce Co-Promotion of CIMZIA (certolizumab pegol) for the Treatment of Adults with Moderate to Severe Crohn's...