Summary: Researchers identified a brain circuit that harmonizes vocalization with breathing, ensuring that speech occurs predominantly during exhalation. This circuit, which regulates the larynxs narrowing and the act of exhaling, is under the influence of a brainstem area responsible for the breathing rhythm.
By studying mice, the team discovered that this vocalization circuit receives inhibitory signals from the pre-Btzinger complex during inhalation, preventing speech. This groundbreaking discovery not only sheds light on how speech and breathing coordination is neurologically controlled but also suggests a fundamental mechanism shared across species, including humans, underscoring the primacy of breathing over vocalization.
Key Facts:
Source: MIT
MIT researchers have discovered a brain circuit that drives vocalization and ensures that you talk only when you breathe out, and stop talking when you breathe in.
The newly discovered circuit controls two actions that are required for vocalization: narrowing of the larynx and exhaling air from the lungs. The researchers also found that this vocalization circuit is under the command of a brainstem region that regulates the breathing rhythm, which ensures that breathing remains dominant over speech.
When you need to breathe in, you have to stop vocalization. We found that the neurons that control vocalization receive direct inhibitory input from the breathing rhythm generator, says Fan Wang, an MIT professor of brain and cognitive sciences, a member of MITs McGovern Institute for Brain Research, and the senior author of the study.
Jaehong Park, a Duke University graduate student who is currently a visiting student at MIT, is the lead author of the study, which appears today inScience. Other authors of the paper include MIT technical associates Seonmi Choi and Andrew Harrahill, former MIT research scientist Jun Takatoh, and Duke University researchers Shengli Zhao and Bao-Xia Han.
Vocalization control
Located in the larynx, the vocal cords are two muscular bands that can open and close. When they are mostly closed, or adducted, air exhaled from the lungs generates sound as it passes through the cords.
The MIT team set out to study how the brain controls this vocalization process, using a mouse model. Mice communicate with each other using sounds known as ultrasonic vocalizations (USVs), which they produce using the unique whistling mechanism of exhaling air through a small hole between nearly closed vocal cords.
We wanted to understand what are the neurons that control the vocal cord adduction, and then how do those neurons interact with the breathing circuit? Wang says.
To figure that out, the researchers used a technique that allows them to map the synaptic connections between neurons. They knew that vocal cord adduction is controlled by laryngeal motor neurons, so they began by tracing backward to find the neurons that innervate those motor neurons.
This revealed that one major source of input is a group of premotor neurons found in the hindbrain region called the retroambiguus nucleus (RAm). Previous studies have shown that this area is involved in vocalization, but it wasnt known exactly which part of the RAm was required or how it enabled sound production.
The researchers found that these synaptic tracing-labeled RAm neurons were strongly activated during USVs. This observation prompted the team to use an activity-dependent method to target these vocalization-specific RAm neurons, termed as RAmVOC. They used chemogenetics and optogenetics to explore what would happen if they silenced or stimulated their activity.
When the researchers blocked the RAmVOCneurons, the mice were no longer able to produce USVs or any other kind of vocalization. Their vocal cords did not close, and their abdominal muscles did not contract, as they normally do during exhalation for vocalization.
Conversely, when the RAmVOCneurons were activated, the vocal cords closed, the mice exhaled, and USVs were produced. However, if the stimulation lasted two seconds or longer, these USVs would be interrupted by inhalations, suggesting that the process is under control of the same part of the brain that regulates breathing.
Breathing is a survival need, Wang says. Even though these neurons are sufficient to elicit vocalization, they are under the control of breathing, which can override our optogenetic stimulation.
Rhythm generation
Additional synaptic mapping revealed that neurons in a part of the brainstem called the pre-Btzinger complex, which acts as a rhythm generator for inhalation, provide direct inhibitory input to the RAmVOCneurons.
The pre-Btzinger complex generates inhalation rhythms automatically and continuously, and the inhibitory neurons in that region project to these vocalization premotor neurons and essentially can shut them down, Wang says.
This ensures that breathing remains dominant over speech production, and that we have to pause to breathe while speaking.
The researchers believe that although human speech production is more complex than mouse vocalization, the circuit they identified in mice plays the conserved role in speech production and breathing in humans.
Even though the exact mechanism and complexity of vocalization in mice and humans is really different, the fundamental vocalization process, called phonation, which requires vocal cord closure and the exhalation of air, is shared in both the human and the mouse, Park says.
The researchers now hope to study how other functions such as coughing and swallowing food may be affected by the brain circuits that control breathing and vocalization.
Funding: The research was funded by the National Institutes of Health.
Author: Sarah McDonnell Source: MIT Contact: Sarah McDonnell MIT Image: The image is credited to Neuroscience News
Original Research: The findings will appear in Science
See the original post:
Brain Circuit Balances Speech and Breath - Neuroscience News
- Neuroscience Says Music Is an Emotion Regulation Machine. Heres What to Play for Happiness, Productivity, or Deep Thinking - Inc.com - April 19th, 2025 [April 19th, 2025]
- Early Maternal Affection Shapes Key Personality Traits for Life - Neuroscience News - April 19th, 2025 [April 19th, 2025]
- Elons new neuroscience major highlighted by Greensboro News & Record - Elon University - April 19th, 2025 [April 19th, 2025]
- Brain Blast event at St. Lawrence University teaches local students neuroscience - North Country Now - April 19th, 2025 [April 19th, 2025]
- AI Reveals What Keeps People Committed to Exercise - Neuroscience News - April 19th, 2025 [April 19th, 2025]
- The "Holy Grail" of Neuroscience? Researchers Create Stunningly Accurate Digital Twin of the Brain - The Debrief - April 19th, 2025 [April 19th, 2025]
- Annenberg School Vice Dean Emily Falk publishes book on the neuroscience of decision-making - The Daily Pennsylvanian - April 19th, 2025 [April 19th, 2025]
- Music-Induced Chills Trigger Natural Opioids in the Brain - Neuroscience News - April 19th, 2025 [April 19th, 2025]
- What We Value: The Neuroscience of Choice and Change - think.kera.org - April 19th, 2025 [April 19th, 2025]
- Kile takes top neuroscience post at Sutter Health as system pushes to align care, expand trials - The Business Journals - April 19th, 2025 [April 19th, 2025]
- A Grain of Brain, 523 Million Synapses, and the Most Complicated Neuroscience Experiment Ever Attempted - SciTechDaily - April 19th, 2025 [April 19th, 2025]
- Mild Brain Stimulation Alters Decision-Making Speed and Flexibility - Neuroscience News - April 19th, 2025 [April 19th, 2025]
- Cannabis studies were informing fundamental neuroscience in the 1970s - Nature - April 10th, 2025 [April 10th, 2025]
- To make a meaningful contribution to neuroscience, fMRI must break out of its silo - The Transmitter - April 10th, 2025 [April 10th, 2025]
- Steve Jobss Unexpected Secret to Being More Creative (Backed by Neuroscience) - Inc.com - April 10th, 2025 [April 10th, 2025]
- Challenging Decades of Neuroscience: Brain Cells Are More Plastic Than Previously Thought - SciTechDaily - April 10th, 2025 [April 10th, 2025]
- Q&A: Lundbecks head of R&D on letting biology speak in neuroscience - Endpoints News - April 10th, 2025 [April 10th, 2025]
- Why it's hard to study the neuroscience of psychedelics : Short Wave - NPR - April 10th, 2025 [April 10th, 2025]
- Fear Sync: How Males and Females Respond to Stress Together - Neuroscience News - April 10th, 2025 [April 10th, 2025]
- Chemotherapy Disrupts Brain Connectivity - Neuroscience News - April 10th, 2025 [April 10th, 2025]
- Newly awarded NIH grants for neuroscience lag 77 percent behind previous nine-year average - The Transmitter - April 10th, 2025 [April 10th, 2025]
- Wittstein interviewed by The Times News about new neuroscience major - Elon University - April 10th, 2025 [April 10th, 2025]
- Alto Neuroscience initiated with a Buy at H.C. Wainwright - Yahoo Finance - April 10th, 2025 [April 10th, 2025]
- New map of brain hailed as watershed for neuroscience - The Times - April 10th, 2025 [April 10th, 2025]
- GSK Ramps Up Neuroscience Investment With ABL Brain Shuttle Deal - insights.citeline.com - April 10th, 2025 [April 10th, 2025]
- ADHD and Music: Why Background Beats May Boost Study Focus - Neuroscience News - April 10th, 2025 [April 10th, 2025]
- Brains Rewire Themselves to Survive Deadly Infection - Neuroscience News - April 10th, 2025 [April 10th, 2025]
- AbbVie Hold Rating: Balancing Strong Immunology Growth with Challenges in Aesthetics, Neuroscience, and Oncology - TipRanks - April 10th, 2025 [April 10th, 2025]
- Want to Feel Better and Be More Mindful? Neuroscience Says This Habit Might Be Holding You Back - Inc.com - April 10th, 2025 [April 10th, 2025]
- How One Bad Meal Rewires the Brain to Avoid That Food Forever - Neuroscience News - April 10th, 2025 [April 10th, 2025]
- Marcus Neuroscience Institute to Host Brain and Spine Symposium - South Florida Hospital News - March 30th, 2025 [March 30th, 2025]
- Elon University to launch neuroscience major in fall 2025 - Today at Elon - March 30th, 2025 [March 30th, 2025]
- The brains stalwart sentinels express an unexpected gene - The Transmitter: Neuroscience News and Perspectives - March 30th, 2025 [March 30th, 2025]
- Video catches microglia in the act of synaptic pruning - The Transmitter: Neuroscience News and Perspectives - March 30th, 2025 [March 30th, 2025]
- Null and Noteworthy: Reexamining registered reports - The Transmitter: Neuroscience News and Perspectives - March 30th, 2025 [March 30th, 2025]
- Accepting the bitter lesson and embracing the brains complexity - The Transmitter: Neuroscience News and Perspectives - March 30th, 2025 [March 30th, 2025]
- NIH neurodevelopmental assessment system now available as iPad app - The Transmitter: Neuroscience News and Perspectives - March 30th, 2025 [March 30th, 2025]
- Stronger Bonds Before Birth Shape Healthier Mother-Child Futures - Neuroscience News - March 30th, 2025 [March 30th, 2025]
- How Emotionally Intelligent People Learn to Control Their Inner Voice, Backed by Neuroscience - Inc. - March 30th, 2025 [March 30th, 2025]
- Gabriele Scheler reflects on the interplay between language, thought and AI - The Transmitter: Neuroscience News and Perspectives - March 30th, 2025 [March 30th, 2025]
- Worlds first crowd-sourced neuroscience study aims to understand how our brains predict the future - EurekAlert - March 15th, 2025 [March 15th, 2025]
- Rewriting Neuroscience: Possible Foundations of Human Intelligence Observed for the First Time - SciTechDaily - March 15th, 2025 [March 15th, 2025]
- Calculating neurosciences carbon cost: Q&A with Stefan Pulver and William Smith - The Transmitter: Neuroscience News and Perspectives - March 15th, 2025 [March 15th, 2025]
- The future of neuroscience research at U.S. minority-serving institutions is in danger - The Transmitter: Neuroscience News and Perspectives - March 15th, 2025 [March 15th, 2025]
- Dopamine and social media: Why you cant stop scrolling, according to neuroscience - PsyPost - March 15th, 2025 [March 15th, 2025]
- Neuroscience Discovered a Clever Trick for Squeezing More Joy Out of Everyday Pleasures - Inc. - March 15th, 2025 [March 15th, 2025]
- The limits of neuroscience - The Transmitter: Neuroscience News and Perspectives - March 15th, 2025 [March 15th, 2025]
- BPOM Explains The Benefits Of Fasting From The Health And Neuroscience Side - VOI English - March 15th, 2025 [March 15th, 2025]
- How tiny tardigrades could help tackle systems neuroscience questions - The Transmitter: Neuroscience News and Perspectives - March 15th, 2025 [March 15th, 2025]
- Alison Preston explains how our brains form mental frameworks for interpreting the world - The Transmitter: Neuroscience News and Perspectives - March 15th, 2025 [March 15th, 2025]
- The Mystical Mind Meets Neuroscience: Seeking the Roots of Consciousness - Next Big Idea Club Magazine - March 15th, 2025 [March 15th, 2025]
- Myosin Therapeutics Closes Second Seed Round to Advance Clinical Trials for Innovative Cancer and Neuroscience Therapies - PR Newswire - March 5th, 2025 [March 5th, 2025]
- Neuroscience Ph.D. programs adjust admissions in response to U.S. funding uncertainty - The Transmitter: Neuroscience News and Perspectives - March 5th, 2025 [March 5th, 2025]
- New tools help make neuroimaging accessible to more researchers - The Transmitter: Neuroscience News and Perspectives - March 5th, 2025 [March 5th, 2025]
- Future Thinking Training Reduces Impulsivity - Neuroscience News - March 5th, 2025 [March 5th, 2025]
- Null and Noteworthy, relaunched: Probing a schizophrenia biomarker - The Transmitter: Neuroscience News and Perspectives - March 5th, 2025 [March 5th, 2025]
- How to communicate the value of curiosity-driven research - The Transmitter: Neuroscience News and Perspectives - March 5th, 2025 [March 5th, 2025]
- Cognitive neuroscience approach to explore the impact of wind turbine noise on various mental functions - Nature.com - March 5th, 2025 [March 5th, 2025]
- Football on the Brain: Helping coaches embed neuroscience knowledge - Training Ground Guru - March 5th, 2025 [March 5th, 2025]
- Taking Control: Using Neuroscience to Build Better Lives - theLoop - March 5th, 2025 [March 5th, 2025]
- Creating a pipeline of talent to feed the growth of Neuroscience: Lessons from Ghana - Myjoyonline - March 5th, 2025 [March 5th, 2025]
- Exclusive: NIH appears to archive policy requiring female animals in studies - The Transmitter: Neuroscience News and Perspectives - February 25th, 2025 [February 25th, 2025]
- Roll On Down The Highway 2025 Tour coming to Neuroscience Group Field - WeAreGreenBay.com - February 25th, 2025 [February 25th, 2025]
- STEM organizations host Neuroscience Outreach Fair for local K-12 students - University of Virginia The Cavalier Daily - February 25th, 2025 [February 25th, 2025]
- Adapt or die: Safeguarding the future of diversity and inclusion funding in neuroscience - The Transmitter: Neuroscience News and Perspectives - February 25th, 2025 [February 25th, 2025]
- The last two-author neuroscience paper? - The Transmitter: Neuroscience News and Perspectives - February 25th, 2025 [February 25th, 2025]
- Gate Neurosciences Strengthens Focus on the Synapse as a Therapeutic Target with Acquisition of Boost Neuroscience - Business Wire - February 25th, 2025 [February 25th, 2025]
- Why Firefly Neuroscience, Inc. (AIFF) Is Soaring This Year So Far - Yahoo Finance - February 25th, 2025 [February 25th, 2025]
- Breaking the barrier between theorists and experimentalists - The Transmitter: Neuroscience News and Perspectives - February 25th, 2025 [February 25th, 2025]
- Preserving Brain Health and Advancing Neuroscience - University of Miami - February 25th, 2025 [February 25th, 2025]
- Science must step away from nationally managed infrastructure - The Transmitter: Neuroscience News and Perspectives - February 25th, 2025 [February 25th, 2025]
- Repurposed Blood Pressure Drug May Treat ADHD - Neuroscience News - February 25th, 2025 [February 25th, 2025]
- How to teach students about science funding - The Transmitter: Neuroscience News and Perspectives - February 25th, 2025 [February 25th, 2025]
- Reflecting on 2024: Advancing Neuroscience Research to Improve Neurological Health - National Institute of Neurological Disorders and Stroke - February 25th, 2025 [February 25th, 2025]
- Brains Hidden Circuitry for Risk and Reward Uncovered - Neuroscience News - February 25th, 2025 [February 25th, 2025]
- Why We Keep Exploring Even After Learning the Best Strategy - Neuroscience News - February 25th, 2025 [February 25th, 2025]
- Unlocking Cellular Youth: The Protein That Reverses Aging - Neuroscience News - February 25th, 2025 [February 25th, 2025]
- This paper changed my Life: Bill Newsome reflects on a quadrilogy of classic visual perception studies - The Transmitter: Neuroscience News and... - February 25th, 2025 [February 25th, 2025]
- Roundup: The false association between vaccines and autism - The Transmitter: Neuroscience News and Perspectives - February 3rd, 2025 [February 3rd, 2025]
- Static pay, shrinking prospects fuel neuroscience postdoc decline - The Transmitter: Neuroscience News and Perspectives - February 3rd, 2025 [February 3rd, 2025]