Summary: A collaborative team is developing a neural fiber to combat Alzheimers disease. This high-priority NIH-funded project aims to create a minimally invasive fiber, capable of electrical stimulation and drug delivery, to study and potentially reverse memory loss.

The fiber will enable detailed imaging and analysis of amyloid deposits in the brain, a key factor in Alzheimers. With a one-year deadline, this ambitious project could revolutionize our approach to understanding and treating Alzheimers.

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Source: Virginia Tech

Every 65 seconds, someone in the United States develops Alzheimers disease, a devastating form of dementia that affects 6.2 million Americans.

Though it was initially identified almost 120 years ago, Alzheimers diseaseis a progressive neurological disorder with no cure and few treatments. It starts out with minor memory loss that, over time, advances to a mental decline so severe, individuals have difficulty even swallowing.

Xiaoting Jia, associate professor in theBradley Department of Electrical and Computer Engineering, experienced the direct, cruel impact of Alzheimers diseaseas it ravaged her grandmothers mind, destroying memories of a long-lived and loved life.

Alzheimers is a devastating problem Ive seen firsthand how bad it could be, Jia said. Its why it concerns me as an electrical engineer. I want to build tools and try to assist neuroscientists in solving brain problems.

Its this personal connection that makes thehigh priority, short-term grant from the National Institutes of Healthso poignant.

A pioneer in the neural fiber field, Jia has partnered with longtime collaboratorHarald Sontheimer, professor and chair of neuroscience at the University of Virginia, and fellow brain imaging expertSong Hu, associate professor of biomedical engineering at Washington University in St. Louis, on the development of a new neural tool: a deep brain, multipurpose fiber.

Their goal? Slowing down or reversing memory loss.

Examples of previous preform pulled through Xiaoting Jias thermal fiber drawing tower. The preform gets thinner and thinner as its pulled, creating the tube that houses different fibers or filaments. Photo by Ben Murphy for Virginia Tech.

What we are doing here together is creating a device with which we can visualize the build up of biomarkers that are the culprits of Alzheimers disease, Sontheimer said. Usually you cant access or image that part of the brain, but this device will provide access to the hippocampus, home of spatial memory and retention.

The team has one year to build a minimally invasive, long-term fiber not much thicker thana strand of hair to study those biomarkers, including thick protein deposits called amyloids in the hippocampus.

Current electrical and imaging toolsby neuroscientists are limited in resolution, both time and spatial, such as an MRI or electroencephalogram. Some are more invasive with large electrodes with which doctors need to fish around in an attempt to apply electrical stimulation to the deep brain.

A big problem in Alzheimers research is there are a lot of dysfunctions in the brain having to do with neurovascular changes, Hu said, but we dont totally understand how those changes impact memory loss and behaviors that eventually impair their life. Conventional techniques have provided an important understanding of neurons and vasculature, but theres a technology limitation.

The super fiber Jia will construct stands out from other existing technologies because of the flexible polymer platform. Little to no damage of brain tissue and long-lasting potential means fewer complicated surgeries, and more time with family.

Amyloid deposits are the main feature for AD [Alzheimers disease], and they begin developing years, even decades, before people show AD symptoms, Jia said. Its still a mystery how the deposits even begin.

According to Jia, theres no confirmed causal relationship between Alzheimers diseaseand the deposits yet. However, the relationship between plaque buildup and the onset of symptoms is the guiding focus of the teams research, with each researcher taking on a key component in the creation of this first-of-its-kind fiber:

Xiaoting Jia holds up an example of the embedded fiber the team would use in its research. Photo by Peter Means for Virginia Tech.

Target one for the team is to utilize the endoscope. It will provide images to the team for observing neuroactivity, the initial stages of amyloid deposition, and the blood flow in vessels. The team will use this data to analyze the memory loss-amyloid relationship.

Target two is sending electrical pulses and later, anti-amyloid drugs in the hopes of re-establishing blood flow and oxygenation to dead neurons and restoring memory.

If that sounds complex it is. And the team only has 12 months to develop and test two prototypes.

This is a very ambitious goal, what were trying to do in one year, Jia said. The brain is very nuanced with more than 80 billion neurons, and were still behind on fully understanding how the brain functions and how diseases are formed.

Achieving its targets will enable the fiber team to seek additional multiyear funding from the National Institutes of Health. The ultimate hope? The researchers will be able to prove their technology has the possibility to improve the quality of life for the millions of Americans impacted by Alzheimers disease.

Author: Chelsea Seeber Source: Virginia Tech Contact: Chelsea Seeber Virginia Tech Image: The image is credited to Neuroscience News

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Innovative Fiber to Tackle Alzheimer's Developed - Neuroscience News