Summary: People with higher levels of omega-3 DHA in their blood are 49% less likely to develop dementia than those with lower levels. Researchers say adding additional omega-3 DHA to the diet, especially in those with the Alzheimers associated Apoe4 gene, could slow the development and progress of dementia.

Source: Wright On Marketing & Communications

New research published today inNutrientsshows that people with a higher blood DHA level are 49% less likely to develop Alzheimers disease vs. those with lower levels, according to theFatty Acid Research Institute(FARI).

The study, led by Aleix Sala-Vila, PhD, suggested that providing extra dietary omega-3 DHA, especially for those carrying the ApoE4 gene (which approximately doubles an individuals susceptibility to develop AD) might slow the development of the disease.

Such a cost-effective, low-risk dietary intervention like this could potentially save billions in health care costs.

In this prospective observational study conducted within theFramingham Offspring Cohort including 1490 dementia-free participants aged 65 years old researchers examined the association of red blood cell (RBC) docosahexaenoic acid (DHA) with incident Alzheimers Disease (AD), while also testing for an interaction with APOE-4 carriership.

Risk for incident AD in the highest RBC DHA quintile (Q5, >6.1%) was 49% lower compared with the lowest quintile (Q1, <3.8%). An increase in RBC DHA from Q1 to Q5 was predicted to provide an estimated 4.7 additional years of life free of AD.

Further, the researchers noted that an increased intake of DHA might lower risk for developing AD, particularly in higher-risk individuals such as those carrying theAPOE-4 allele, suggestingthat they may benefit more from higher DHA levels than non-carriers.

The public health impact of preventing AD with something as simple as a dietary intervention like DHA is also significant.

The researchers noted that Given that estimated health-care payments in 2021 for all patients with AD or other dementias amount to $355 billion in the US (not including caregiving by family members and other unpaid caregivers), any cost-effective strategy for delaying the onset of AD is of utmost public health interest, and that Delaying AD by 5 years leads to 2.7 additional years of life, and 4.8 additional AD-free years for an individual who would have acquired AD and is worth over $500,000.

So how does this paper stack up to others in this area? Our study is in line with that ofTan et al.who reported cross-sectional associations with RBC DHA on cognitive performance and brain volume measurements (with higher DHA being associated with beneficial outcomes) in the same cohort as studied here, said William S. Harris, PhD, President of FARI, and senior author on this recent study.

Most interestingly, 15 years ago similar findings were reported bySchaefer et al.in the parents of the individuals who were the focus of this present investigation (i.e., the Original Framingham Heart Study cohort).

Schaefer et al. reported that participants in the top quartile of plasma phosphatidylcholine DHA experienced a significant, 47% reduction in the risk of developing all-cause dementia compared with those with lower levels, Dr. Harris continued.

Similar findings a generation apart in a similar genetic pool provide considerable confirmation of this DHA-dementia relationship.

Author: Becky WrightSource: Wright on Marketing & CommunicationsContact: Becky Wright Wright On Marketing & CommunicationsImage: The image is in the public domain

Original Research: The findings will appear in Nutrients

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People With a High Omega-3 DHA Level in Their Blood Are at 49% Lower Risk of Alzheimer's - Neuroscience News