Summary: A new study explores the molecular connections between Type 2 diabetes and Alzheimers, supporting the notion of Alzheimers as Type 3 diabetes.

This study finds that a high-fat diet suppresses a crucial gut protein, Jak3, leading to Alzheimers-like brain changes in mice. It underscores the importance of managing diabetes or avoiding it through diet to reduce Alzheimers risk.

The findings illuminate a potential path from diet through gut inflammation to brain health, offering hope for preventative strategies.

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Source: ASBMB

New research conducted in mice offers insights into whats going on at the molecular level that could cause people with diabetes to develop Alzheimers disease.

The study adds to a growing body of research on the links between Type 2 diabetes and Alzheimers disease, which some scientists have called Type 3 diabetes.

The findings suggest that it should be possible to reduce the risk of Alzheimers by keeping diabetes well controlled or avoiding it in the first place, according to researchers.

NarendraKumar, an associate professor at Texas A&M University in College Station, led the study.

We think that diabetes and Alzheimers disease are strongly linked, Kumar said, and by taking preventative or amelioration measures for diabetes, we can prevent or at least significantly slow down the progression of the symptoms of dementia in Alzheimers disease.

Kumar will present the new research atDiscover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, which is being held March 2326 in San Antonio.

Diabetes and Alzheimers are two of the fastest-growing health concerns worldwide. Diabetes alters the bodys ability to turn food into energy and affects an estimated 1 in 10 U.S. adults. Alzheimers, a form of dementia that causes progressive decline in memory and thinking skills, is among the top 10 leading causes of death in the United States.

Diet is known to influence the development of diabetes as well as the severity of its health impacts. To find out how diet could influence the development of Alzheimers in people with diabetes, the researchers traced how a particular protein in the gut influences the brain.

They found that a high-fat diet suppresses the expression of the protein, called Jak3, and that mice without this protein experienced a cascade of inflammation starting with the intestine, moving through the liver and on to the brain.

Ultimately, the mice showed signs of Alzheimers-like symptoms in the brain, including an overexpressed mouse beta-amyloid and hyperphosphorylated tau, as well as evidence of cognitive impairment.

Liver being the metabolizer for everything we eat, we think that the path from gut to the brain goes through liver, Kumar said.

His lab has been studying functions of Jak3 for a long time, he added, and they now know that the impact of food on the changes in the expression of Jak3 leads to leaky gut. This in turn results in low-grade chronic inflammation, diabetes, decreased ability of the brain to clear its toxic substances and dementia-like symptoms seen in Alzheimers disease.

The good news, according to Kumar, is that it may be possible to stop this inflammatory pathway by eating a healthy diet and getting blood sugar under control as early as possible.

In particular, people with prediabetes which includes an estimated 98 million U.S. adults could benefit from adopting lifestyle changes to reverse prediabetes, prevent the progression to Type 2 diabetes and potentially reduce the risk of Alzheimers.

Author: Anne Johnson Source: ASBMB Contact: Anne Johnson ASBMB Image: The image is credited to Neuroscience News

Original Research: The findings will be presented at Discover BMB

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Study Links Diet, Diabetes, and Alzheimers - Neuroscience News