Summary: During brain development, oligodendrocyte precursor cells (OPCs) contribute to the neural pruning process, helping to shape the healthy development of the brain.

Source: CSHL

When the brain first wires itself up in early development, it creates more connections than it actually needs.

Some of these connections, or synapses, will transmit critical signals as young animals begin to sense their surroundings. Others will be eliminated as the brain matures.

Only those that the animal needs to understand and interact with the world are left.

Cold Spring Harbor Laboratory (CSHL) Assistant Professor Lucas Cheadle and colleagues have discovered that cells called oligodendrocyte precursor cells (OPCs) contribute to this pruning process. This helps shape a healthybrainduring early development.

Understanding this vital part of brain development may reveal new strategies for treating neurodevelopmental conditions like schizophrenia andautism spectrum disorder(ASD).

The discovery was sparked while using high-powered microscopes to examine the brains of adult mice. Cheadles team noticed that many OPCs were actively engulfing the connection points between neurons.

The team suspected the cells might be busy eliminating synapses that the brain did not need. Cheadle and his team wondered if OPCs did the same thing in younger brains. A young animals experiences have a particularly profound impact on shaping neural circuits duringearly development.

The researchers raised young mice in the dark. When the mice were first exposed to light, OPCs began engulfingsynapsesin response. The cells were operating in their brains vision-processing circuitry.

OPCs seem to be especially poised to regulate brain connections associated with experiences, Cheadle says. These cells are very responsive to new experiences. They can take that information and use it to shape brain connections.

Published inNature Neuroscience, the Cheadle teams discovery reveals an unexpected role for OPCs. Several kinds of cells help shapeneural circuitsby eliminating unnecessary connections. OPCs had previously only been known for producing cells that surround and support neurons.

Cheadle says, This is a cell type thats really poised to sort of serve as an intermediary between whats going on in the world out there and whats happening inside of our brains.

Cheadle hopes this new information will help understand neurodevelopmental disorders better. He plans to investigate whether faulty OPC pruning plays a role in conditions like schizophrenia and ASD.

Author: Press OfficeSource: CSHLContact: Press Office CSHLImage: The image is credited to Cheadle lab/Imaris software/CSHL, 2022

Original Research: Open access.Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice by Yohan S. S. Auguste et al. Nature Neuroscience

Abstract

Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice

Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited to oligodendrogenesis.

Here we show that OPCs contribute to thalamocortical presynapse elimination in the developing and adult mouse visual cortex. OPC-mediated synapse engulfment increases in response to sensory experience during neural circuit refinement.

Our data suggest that OPCs may regulate synaptic connectivity in the brain independently of oligodendrogenesis.

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The Unexpected Cells Helping to Shape Young Brains - Neuroscience News