C. Shan Xu named Harvey and Kate Cushing Professor of Physiology – Yale News

C. Shan Xu

C. Shan Xu, a pioneer in the field of instrumentation development, has been appointed Harvey and Kate Cushing Professor of Physiology, effective July 1.

Xu is a graduate of the University of Science and Technology of China and earned his Ph.D. in physical chemistry from the University of California, Berkeley in 1997. He was a technical director in charge of research, development, and dissemination of advanced semiconductor technologies at Lam Research Corporation. In 2009, Xu joined the Janelia Research Campus of Howard Hughes Medical Institute as a senior scientist to develop enhanced focused ion beam-scanning electron microscopy (FIB-SEM) and later became the director of FIB-SEM technologies. He was recently recruited to Yale to further develop the next generation FIB-SEM technologies as a senior faculty member in the Department of Cellular and Molecular Physiology.

A pioneer in instrumentation development, Xu holds more than 20 patents and is known for his work transforming conventional FIB-SEM from a metrology tool that is unreliable for more than a few days to a robust imaging platform with 100% effective reliability: capable of years of continuous imaging without defects in the final image stack. The enhanced FIB-SEM technology was initially invented to generate the largest and most detailed brain connectome to date, and was recently used to create an open-access, 3D atlas of whole cells and tissues at the finest isotropic resolution, including cancer and immune cells, mouse pancreatic islets, and Drosophila neural tissues. The story was featured in Nature and The Scientist. This technology has enabled significant discoveries in tissue biology, cell biology, and neuroscience where nano-scale resolution coupled with meso and even macro scale volumes is critical. In addition to technology development, Xu is well known for his leadership in disseminating enhanced FIB-SEM technology to worldwide research community.

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C. Shan Xu named Harvey and Kate Cushing Professor of Physiology - Yale News

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