Rep. Brian Higgins has announced that UB has received a five-year, $2,224,925 grant from the National Institutes of Health to develop a method to diagnose Parkinsons disease (PD) before clinical symptoms are present.

The funding was awarded by the National Institute of Neurological Disorders and Stroke of the NIH. Principal investigator is Jian Feng, professor of physiology and biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB.

Parkinsons is a motor system disorder resulting from the loss of dopamine-producing cells in the brain. It currently is diagnosed by neurologists observing and rating clinical symptoms based on a standard criteria. To even exhibit the onset of clinical symptoms of PD, one must experience many decades of cellular deterioration.

UBsresearch aims to transform Parkinsons research and therapeutic development with the ability to diagnose PD earlier, allowing for the possibility of proactively preventing or delaying severe neuron decay. The research, titled Molecular Segregation of Parkinsons Disease by Patient derived Neurons will also aim to identify and separate two major subtypes of PD those who experience tremors and those who do not to be able to better treat specific types of PD.

The National Institutes of Health estimates that up to 1 million people in the United States may have Parkinsons disease. Thats 1 million Americans with a difficult, progressive condition without a cure who must wait until their clinical symptoms are serious enough to be diagnosed, Higgins said. This federal investment to assist our Western New York researchers hopes to provide a path to earlier detection of Parkinsons to attempt treatment as quick as possible.

When we generated induced pluripotent stem cells from a group of Parkinsons disease patients and a group of normal subjects, we found that there were many significant differences in the expression levels of genes controlling the production, utilization and degradation of dopamine, Feng said. Thus, we want to investigate this further with the goal of developing a method for the objective diagnosis of Parkinsons disease. It might also allow us to predict years in advance who may develop Parkinsons.

Higgins has been an advocate for measures that advance Parkinsons research and treatment.Following meetings with the Michael J. Fox Foundation,the Parkinsons Foundation of WNY and local advocate and former congressman Jack Quinn, Higgins sent a letter to the Department of Veterans Affairs and the Department of Health and Human Services last January urging that access to boxing therapy in the treatment of Parkinsons be expanded, as well as more research be conducted to document the efficacy of the program.In February, he drafted a bipartisan letter supporting funding for a surveillance database at the Centers for Disease Control and Prevention to collect vital demographic information on people living with neurological diseases,a measure supported by the Michael J. Fox Foundation.

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Higgins announces $2.2 million grant to UB to support Parkinson's research - UB Now: News and views for UB faculty and staff - University at Buffalo...