2020

Elevated circulating amyloid promotes concentrations in obesity and diabetes promote vascular dysfunction. , Journal of Clinical Investigation

2018

Small vessels, dementia and chronic diseases molecular mechanisms and pathophysiology. , Clinical Science

2018

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice. , Scientific Reports

2018

The beta secretase BACE1 regulates the expression of the insulin receptor in the liver. , Nature Communications

2018

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of Keap1, Nature

2018

The BACE1 product sAPP induces ER stress, inflammation and attenuates insulin signaling in skeletal muscle. , Metabolism

2016

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation., Scientific Reports

2015

Beta2-integrin knock-in mice remain glucose tolerant in spite of insulin resistance, neutrophil infiltration and inflammation. , PLoS One

2015

Neuronal development is promoted by weakened intrinsic antioxidant defenses due to epigenetic repression of Nrf2, Nature Communications

2015

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1b production via NRF2-mediated counter-regulation of the inflammasome., Journal of Autoimmunity

2014

The susceptibility of Nrf2-null mice to hepatic steatosis and cirrhosis upon consumption of a high-fat diet is associated with a profound disturbance in metabolic enzymes in the liver, but not with insulin resistance. , Journal of Cell Biology

2014

Antioxid Redox Phosphoinositide 3-kinases upregulate system xc- via eIF2 and ATF4 a pathway active in glioblastomas and epilepsy. , Antioxidant & Redox Signaling

2014

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes. , PNAS

2014

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes. , Diabetologia

2013

Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression. , Neurosignals

2011

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. , Biochemical Journals

2010

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. , Free Radical Biology and Medicine

2010

The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the down-regulation of protein synthesis. , American Journal of Physiology-Endocrinology and Metabolism

2007

Fructose metabolism in the adult mouse optic nerve, a central white matter tract. , Journal of Cerebral Blood Flow & Metabolism

2006

Fructose supports energy metabolism of some, but not all, axons in adult mouse optic nerve. , Journal of Neurophysiology

Continued here:
Paul Meakin - The Conversation UK