Image of a primary neuronal cell culture with detection of MAP2 dendritic marker (red) and Neurofilament axon marker (green).

Promoting the signalling pathway of reelin an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to counterbalance the main cognitive, biochemical and behavioural alterations seen in Alzheimers and other pathologies associated with Tau protein, as shown in a new study with animal models published in the journal Progress in Neurobiology.

The study proves the determining role of reelin in the modulation of pathological processes associated with Alzheimers and other tauopathies (accumulation of amyloid plaques, aberrant distribution of Tau phosphorylated, synaptic dysfunction and memory loss), and opens a new perspective to design future therapeutical targets and drugs to fight these disorders.

The first author of this study is the researcher Daniela Rossi, and it is led by Eduardo Soriano and Llus Pujadas, members of the Faculty of Biology and the Institute of Neurosciences (UBNeuro) of the University of Barcelona, the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) and the Vall dHebron Research Institute (VHIR).

Other participants are the experts Agns Gruart, Jos M Delgado and Gerardo Contreras-Murillos (University Pablo de Olavide), Jess vila (Center for Molecular Biology Severo Ochoa, CBM), and Ashraf Muhaisen (UB-UBNeuro-CIBERNED-VHIR). This new study on neurosciences counts on the support of the Research Challenges program (Biomedicine) from the Spanish Ministry of Economy and Competitiveness (MINECO) and La Marat de TV3.

Reelin, an essential protein for brain plasticity

Alzheimers disease is a neurodegenerative disease known for the loss of connection between neurons and neuronal death. It is largely linked to the creation of senile plaques (formed by the amyloid-beta peptide, or A), and the presence of neurofibrillary balls (insoluble deposit of Tau).

In the adult brain, the loss of reelin has been related to an increase in the phosphorylation of Tau protein a factor which is related to the microtubules mainly expressed in neurons- which ends up in neurofibrillary ball form typical from Alzheimers.

Therefore, the different states of phosphorylation and dephosphorylation of Tau represent a determining factor in the stability of the cell cytoskeleton and, as a result, of the synaptic and dendritic stability. Hyperphosphorilation and accumulation of Tau causes neuronal death.

In this context, the function of the reelin protein to promote synaptic plasticity and reduce Tau phosphorylation was considered a potential mechanism to reduce the consequences of the neurodegenerative process and protect the brain from neuronal damage.

New beneficial effects of reelin in animal models with tauopahy

In previous studies, experts had affirmed the alteration of reelin in Alzheimers disease and its role in intracellular signalling pathways related to neuronal survival and the physiology of the adult brain. Researchers had described the active role of reelin in the recovery of cognitive functions and the reduction of fibers of the A peptide in vitro and amyloid deposit in the brain in animal models with Alzheimers (Pujadas et al. Nature Communications, 2014).

The published study in Progress in Neurobiology describes new molecular data on the signalling pathway of reelin and reveals how this protein can reverse the main pathological affectations of Alzheimers at different levels in animal models affected by tauopathies. In particular, the results reveal that overexpression of reelin is able to modulate levels of phosphorylation of the Tau protein in in vivo models.

Moreover, the in vitro studies confirm the ability of reelin to modulate the anomalous distribution of neurofilaments and Tau protein in dendrites, which is shown in the first phases of these neuropathologies. Last, regarding the cognitive and physiological fields, overexpression of reelin revealed an improvement of deficits that affected a new animal model of tauopathy.

Article reference:

Rossi, D.; Gruart, A.; Contreras-Murillo, G; Muhaisen, A.; vila, J.; Delgado-Garca, J.; Pujadas, L.; Soriano, E. Reelin reverts biochemical, physiological and cognitive alterations in mouse models of Tauopathy. Progress in Neurobiology, December, 2019. Doi: https://doi.org/10.1016/j.pneurobio.2019.101743

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Reelin reverts main pathological processes related to Alzheimer's and other tauopathy - Mirage News