Role of Melatonin in the Regulation of Pain | JPR – Dove Medical Press

Shanshan Xie,1,2 Wenguo Fan,2,3 Hongwen He,2,4 Fang Huang1,2

1Department of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Peoples Republic of China; 2Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Peoples Republic of China; 3Department of Anesthesiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Peoples Republic of China; 4Department of Oral Anatomy and Physiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Peoples Republic of China

Correspondence: Fang Huang; Hongwen HeGuanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou 510080, Peoples Republic of ChinaTel +86 20 87330570Fax +86 20 87330709Email hfang@mail.sysu.edu.cn; 497642565@qq.com

Abstract: Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms. Melatonin is involved in many physiological and pathophysiological processes demonstrating antioxidant, antineoplastic, anti-inflammatory, and immunomodulatory properties. Accumulating evidence has revealed that melatonin plays an important role in pain modulation through multiple mechanisms. In this review, we examine recent evidence for melatonin on pain regulation in various animal models and patients with pain syndromes, and the potential cellular mechanisms.

Keywords: melatonin, pain, cellular mechanisms

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Biologists shed light on the physiology and behavior of cormorants and anhingas - Phys.org - January 23rd, 2025 [January 23rd, 2025]
Essential Anatomy & Physiology Textbooks Redefining Manual Therapy Education - EIN News - January 23rd, 2025 [January 23rd, 2025]
SD-25117 PHD ON FOREST SOIL DROUGHT AND SOIL MICROBIAL PHYSIOLOGY AND CARBON PERSISTENCE - Nature.com - November 28th, 2024 [November 28th, 2024]
Exploring the Effects of Masks on Skin Physiology - Dermatology Times - October 26th, 2024 [October 26th, 2024]
Nobel Prize in Physiology or Medicine Awarded for Discovery of MicroRNA Gene Regulation - Scientific American - October 13th, 2024 [October 13th, 2024]
Discovery in Tiny Worm Leads to Nobel Prize in Physiology or Medicine for 2 Scientists - The New York Times - October 13th, 2024 [October 13th, 2024]
Nobel Prize in physiology or medicine awarded for discovery of microRNA - The Washington Post - October 13th, 2024 [October 13th, 2024]
Victor Ambros 75, PhD 79 and Gary Ruvkun share Nobel Prize in Physiology or Medicine - MIT News - October 13th, 2024 [October 13th, 2024]
The physiology of plants in the context of space exploration - Nature.com - October 13th, 2024 [October 13th, 2024]
2024 Nobel Prize in Physiology or Medicine: What is the research that won the prize? | Explained - The Hindu - October 13th, 2024 [October 13th, 2024]
The discovery of microRNA wins the 2024 Nobel Prize in physiology - Science News Explores - October 13th, 2024 [October 13th, 2024]
NSF congratulates laureates of the 2024 Nobel Prize in physiology or medicine - National Science Foundation (.gov) - October 13th, 2024 [October 13th, 2024]
Polyamine impact on physiology of early stages of reef-building coralsinsights from rearing experiments and RNA-Seq analysis - Nature.com - October 13th, 2024 [October 13th, 2024]
Nobel Prize in Physiology or Medicine: Who are Victor Ambros and Gary Ruvkun? - The Economic Times - October 13th, 2024 [October 13th, 2024]
Nobel Prize in Physiology or Medicine awarded to 2 discoverers of microRNA - Fierce Biotech - October 13th, 2024 [October 13th, 2024]
Victor Ambros and Gary Ruvkun Win the Nobel Prize in Physiology or Medicine 2024 - Technology Networks - October 13th, 2024 [October 13th, 2024]
Johns Hopkins University vs. Stanford University: Which University Dominates in Anatomy & Physiology? - The Times of India - October 2nd, 2024 [October 2nd, 2024]
Master of Science in Medical Physiology virtual information session - The Daily | Case Western Reserve University - October 2nd, 2024 [October 2nd, 2024]
Stop saying lactic acid causes fatigue! says physiology expert in response to Games in Paris - Loughborough University - August 5th, 2024 [August 5th, 2024]
Physiological responses of Atlantic cod to climate change indicate that coastal ecotypes may be better adapted to ... - Nature.com - June 9th, 2024 [June 9th, 2024]
Parvalbumin interneuron mGlu5 receptors govern sex differences in prefrontal cortex physiology and binge drinking ... - Nature.com - May 24th, 2024 [May 24th, 2024]
Pharmacology and Physiology Faculty Awarded Grants Totaling $1.5 million - Saint Louis University - May 12th, 2024 [May 12th, 2024]
ESAFE - Postdoctoral Position in Molecular Plant Physiology job with MOHAMMED VI POLYTECHNIC UNIVERSITY ... - Times Higher Education - May 12th, 2024 [May 12th, 2024]
Why psychology is as important as physiology for plastic surgery - The Times - May 12th, 2024 [May 12th, 2024]
Lecturer in Clinical Exercise Physiology (Teaching Level A/B) job with UNIVERSITY OF SOUTH AUSTRALIA | 372763 - Times Higher Education - May 12th, 2024 [May 12th, 2024]
Andrew Nuss: Insect physiology lab - University of Nevada, Reno - February 29th, 2024 [February 29th, 2024]
Professor awarded prestigious honor for contributions to physiology - University of Miami: News@theU - February 29th, 2024 [February 29th, 2024]
Study details five cutting-edge advances in biomedical engineering and their applications in medicine - EurekAlert - February 29th, 2024 [February 29th, 2024]
Contextualizing Cellular Physiology - 2024 - NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) - February 29th, 2024 [February 29th, 2024]
Salk Institute mourns the loss of Nobel Laureate Roger Guillemin, distinguished professor emeritus - Salk Institute - February 29th, 2024 [February 29th, 2024]
Bacterial architects build the biofilm structures - Nature.com - February 13th, 2024 [February 13th, 2024]
I'm a professor of physiology - here are 15 ways cyclists can avoid winter illness - CyclingWeekly - February 13th, 2024 [February 13th, 2024]
Understanding how natural genetic variation contributes to adaptive responses to low oxygen - News-Medical.Net - February 13th, 2024 [February 13th, 2024]
'From slow visual feedback to real-time plant physiology' - Verticalfarmdaily.com: global indoor farming news - February 13th, 2024 [February 13th, 2024]
The Future of Space Biology, Physiology, and Medicine: Exploring the Effects of Gravity on Human Cells - Medriva - February 13th, 2024 [February 13th, 2024]
Master of Science in Medical Physiology program admissions open office hour - The Daily | Case Western Reserve University - January 19th, 2024 [January 19th, 2024]
The Impact of GATAD2B Mutations on Brain Function and Development - Medriva - January 19th, 2024 [January 19th, 2024]
Influence of Sleep-Disordered Breathing and Hypoxia on AF: A Pulmonary Physiological Perspective - Physician's Weekly - December 22nd, 2023 [December 22nd, 2023]
MBRSC to host International Society for Gravitational Physiology meeting - BroadcastProME.com - December 22nd, 2023 [December 22nd, 2023]
If anxiety is in my brain, why is my heart pounding? A psychiatrist explains the neuroscience and physiology of fear - PsyPost - December 22nd, 2023 [December 22nd, 2023]
Renowned Researcher in Physiology to Chair UVA's Department of ... - UVA Health Newsroom - May 5th, 2023 [May 5th, 2023]
Research Fellow (Aging and Cancer Stem Cell Laboratory ... - Times Higher Education - May 5th, 2023 [May 5th, 2023]
Erratum. Integrated Physiology of the Exocrine and Endocrine ... - Diabetes Journal - May 5th, 2023 [May 5th, 2023]
Survey on Value of Flight Nursing Certification Featured in New Air Medical Journal Research Article - Yahoo Finance - May 5th, 2023 [May 5th, 2023]
Positive Relationships Can Keep You Healthy - Medscape - May 5th, 2023 [May 5th, 2023]
Sex Doesn't Have to be a 'Taboo Thing' - Eagle News - May 5th, 2023 [May 5th, 2023]
Kempf and Pakala honored by Boise State Foundation - Boise State University - May 5th, 2023 [May 5th, 2023]
How AI Will Revolutionize Personalized Fitness and Nutrition Plans - MUO - MakeUseOf - May 5th, 2023 [May 5th, 2023]
From the U.S. Navy to Atrium Health: A Nursing Journey - Atrium Health - May 5th, 2023 [May 5th, 2023]
The Importance of PALS Certification for Healthcare Professionals - Eye On Annapolis - May 5th, 2023 [May 5th, 2023]
LPU organized two-day International Conference on Plant ... - :: India News Calling :: - May 5th, 2023 [May 5th, 2023]
Ancient human DNA was extracted from a 20,000-year-old deer ... - Science News Magazine - May 5th, 2023 [May 5th, 2023]
New tusk-analysis techniques reveal surging testosterone in male ... - EurekAlert - May 5th, 2023 [May 5th, 2023]
Effective Physio Care for Mild and Chronic Pain - Movement 101 ... - Digital Journal - May 5th, 2023 [May 5th, 2023]
Real Madrid and Abbott inaugurate the Innovation Lab - Real Madrid - May 5th, 2023 [May 5th, 2023]
Student Poster Presentation Winners Announced | Northern Today - Northern Today - May 5th, 2023 [May 5th, 2023]
From Spiritual Journey to Physiological Phenomena: The ... - Pager Publications, Inc. - May 5th, 2023 [May 5th, 2023]
How 'digital twins' will revolutionise health - Newsroom - May 5th, 2023 [May 5th, 2023]
Conference on role of livestock in food security begins at SKUAST-K - Brighter Kashmir - May 5th, 2023 [May 5th, 2023]
Roles of the gut microbiome in weight management - Nature.com - May 5th, 2023 [May 5th, 2023]
Noted Science Scholar Stuart Dryer Earns 2023 Farfel Award - University of Houston - May 5th, 2023 [May 5th, 2023]
Announcing Virtual Press Conference for the American Physiology Summit - Newswise - April 8th, 2023 [April 8th, 2023]
14 Ohio Indoor Track and Field Members Named Academic All-MAC ... - Ohio University Athletics - April 8th, 2023 [April 8th, 2023]
Imagine a World Where You Control If and When You Go Through ... - Oprah Mag - April 8th, 2023 [April 8th, 2023]
HeartFlow, Leader in Revolutionizing Precision Heart Care, Closes ... - BioSpace - April 8th, 2023 [April 8th, 2023]
Board grants faculty appointments, promotions - The Source ... - Washington University in St. Louis - April 8th, 2023 [April 8th, 2023]
The Productization of Translational Science, Upcoming Webinar ... - PR Web - April 8th, 2023 [April 8th, 2023]
Suicide rate increases during the week of a full moon - Earth.com - April 8th, 2023 [April 8th, 2023]
Innovative method predicts the effects of climate change on cold ... - Science Daily - April 8th, 2023 [April 8th, 2023]
Research Staff Awards honor contributions to discovery | VUMC ... - VUMC Reporter - April 8th, 2023 [April 8th, 2023]
Rady grad students shine at Three Minute Thesis final - UM Today - April 8th, 2023 [April 8th, 2023]
The Physical and Mental Benefits of Stretching Regularly - Laughing Squid - April 8th, 2023 [April 8th, 2023]
Olympic silver medalist calls for Nike boycott after retail giant makes Dylan Mulvaney paid ambassador - Fox News - April 8th, 2023 [April 8th, 2023]
Ethylene transcriptionally regulates cold stress in grapevine leaves - Phys.org - April 8th, 2023 [April 8th, 2023]
Middletown's Libretti inducted into Biology Honor Society at Scranton - themonmouthjournaleastern.com - April 8th, 2023 [April 8th, 2023]
Physical therapist assistant students learn compassion as ... - Pennsylvania State University - April 8th, 2023 [April 8th, 2023]
Risk of ICU Admission and Related Mortality in Patients... : Critical ... - LWW Journals - April 8th, 2023 [April 8th, 2023]
Phi Beta Kappa Selects New Members at UW | News - University of Wyoming News - April 8th, 2023 [April 8th, 2023]
National award honors UB biochemist's transformational leadership promoting inclusivity in science - UBNow: News and views for UB faculty and staff -... - October 12th, 2022 [October 12th, 2022]
These are the real benefits of running, according to the science - Livescience.com - October 12th, 2022 [October 12th, 2022]