Andrs Garca-Snchez, Jorge Ivn Gmez-Nava, Elodia Nataly Daz-de la Cruz, Ernesto Germn Cardona-Muoz, Itzel Nayar Becerra-Alvarado, Javier Alejandro Aceves-Aceves, Esther Nrida Snchez-Rodrguez, Alejandra Guillermina Miranda-Daz

Department of Physiology, University Health Sciences Centre, University of Guadalajara, Guadalajara, Jalisco, Mexico

Correspondence: Alejandra Guillermina Miranda-DazDepartment of Physiology, University Health Sciences Centre, University of Guadalajara, Guadalajara, Jalisco, MexicoEmail kindalex1@outlook.com

Purpose: The increase of visceral abdominal fat (VAF) and oxidative stress (OS) are independent predictors for cardiovascular risk. This study aimed to determine the association of VAF with proinflammatory cytokines, oxidants, antioxidants, and oxidative damage to DNA in subjects with normalweight, overweight, and obesity.PatientsandMethods: A cross-sectional study that included 21 men and 71 women whoattended for a medical check-up was conducted. Dual-energy X-ray absorptiometry (DXA) was used to measure the VAF volume. ELISA and colorimetric techniques were used for chemical analysis.Results: Low activity of superoxide dismutase (SOD) was found in overweight and obese subjects compared to the normalweight group (p=0.005). In contrast, the activity of glutathione peroxidase (GPx) was higher in the overweight and obesity groups compared to the normalweight subjects (p=0.017). The total antioxidant capacity (TAC) was alsoincreased in the overweight group compared to the normalweight group (p=0.04). According to the volume of VAF, the levels of tumor necrosis factor alfa and interleukin 6 showed no differences between subjects with normal and high VAF. Subjects with high VAF show higher levels of 8-isoprostans compared to normal VAF group (p=0.039). Less concentration of 8-oxoguanine-DNA-N-glycosylase-1 (hOGG1) was found in the high VAF group (p=0.032) compared to thenormal VAF subjects. VAF was positively correlated with lipoperoxides (LPO) (r=0.27, p< 0.05) and 8-isoprostanes (r=0.25, p< 0.05). We also found correlations between oxidative stress markers and anthropometric ratios for intra-abdominal fat. The waist-hip ratio was positively correlated with LPO (r=0.30, p< 0.05) and TAC (r=0.24, p< 0.05).Conclusion: These findings suggest that the predominantly oxidative damage associated with VAF in overweight or obesity is lipoperoxidation and oxidative DNA damage. Alterations in endogenous antioxidant defenses may not be linked to the amount of VAF.

Keywords: oxidative stress, oxidative DNA damage, antioxidant enzymes, Lunar iDXA, visceral fat cutoff score

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